It is noteworthy to mention that transfusion guidelines also recommend to consider physiological constitution, hemodynamic and spirometry parameters, volume status, and dynamic of bleeding. In these critical situations hemoglobin (Hb) and/or hematocrit levels are one key factor among others to determine the need for RBC transfusion. Even though infusions or coagulating factors are often administrated to compensate massive blood loss, transfusion of allogenic red blood cells (RBC) is in many cases inevitable. While surgical techniques have advanced over the course of time, intraoperative blood loss is still present in major surgery. ME 3559/3-1 to PM) who had no impact in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist.Īcute anemia is one of the most important and common complication during and after surgery.
#ISTAT HEMOGLOBIN TRIAL#
Data can be obtained by contacting the Clinical Trial Centre Leipzig, University of Leipzig, Härtelstraße 16-19, 04107 Leipzig ( This work is supported by the German Research Foundation (Deutsche Forschungsgemeinschaft grant no. Access can be granted to authorized persons by the sponsor. Thus, it is protected against unauthorized access. Ethical restrictions prevent public sharing of data since the LIBERAL Trial still is a recruiting randomized controlled trial and the database has not been finalized. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: Access restrictions apply to the data underlying the findings. Received: Accepted: SeptemPublished: October 30, 2020Ĭopyright: © 2020 Tanner et al. PLoS ONE 15(10):Įditor: Laura Pasin, Ospedale Sant'Antonio, ITALY A secondary analysis of a randomized controlled trial. (2020) Factors influencing the bias between blood gas analysis versus central laboratory hemoglobin testing. Intraoperative substitution of volume and other co-medications did not influence the bias significantly.Ĭitation: Tanner L, Lindau S, Velten M, Schlesinger T, Wittmann M, Kranke P, et al. The smoker status showed the greatest reduction in bias (0.1 g/dl, p<0.001) whereas BMI (0.07 g/dl, p = 0.0178), RBC transfusion (0.06 g/dl, p<0.001), statins (0.04 g/dl, p<0.05) and beta blocker (0.03 g/dl, p = 0.02) showed a slight effect on bias. A Bland-Altman analysis and LOWESS curve showed that bias decreased with smaller Hb values in absolute numbers but increased relatively.
In order to avoid interference with different standard deviations caused by the different analytic devices, we focused on two centers using the same BGA technique (309 patients and 1,570 Hb pairs).
#ISTAT HEMOGLOBIN SERIES#
Mean bias was comparable between ABL800 Flex analyzer ® and GEM series ®: - 0.38 ± 0.15 g/dl whereas RapidPoint 500 ® showed a smaller bias (-0.09 g/dl) but greater median absolute deviation (± 0.45 g/dl). In total, three centers including 963 patients with 1,814 pairs of Hb measurements were analyzed.